SIBO Product Buyer’s Guide (updated May 2024)

Product Comparison

Approved Science Siboprin
Amy Myers MD Microb-Clear
Integrative Therapeutics Berberine Complex
Dr. Tobias Oregano & Caprylic Acid Blend
Oregano, Barberry & Garlic for antimicrobial properties 
500mg of Oregano to kill bacteria & fungus
Berberine and Allicin to tackle SIBO 
Caprylic acid to support good bacteria & reduce inflammation
Black Pepper extract to boost bioavailability 
Vegan friendly 
Third-party tested for purity
GMP certified
60-day money-back guarantee


SIBO Report


Rating: Excellent


Money-Back Guarantee
Consumer Feedback
Company Reputation

Editor’s Choice

Approved Science Siboprin

If you want to try a powerful supplement to eliminate unwanted bacteria, alleviate SIBO symptoms, reduce inflammation, and improve gut health, then Approved Science Siboprin is something that deserves your undivided attention. Of all the SIBO supplements currently available on the market, this is the one that deserves a closer look and very likely, the one that will change your life!

It contains the recommended herbal ingredients of Oregano, Garlic, and Barberry in a unique Micro-Sci™ Herbal Complex – a synergistic combination to ensure that unwanted bacteria in the small intestines are killed off in an efficient manner. Not only are there substantial quantities of each herb, but they also contain optimal amounts of the most potent constituents: the Barberry extract is standardized to 5% Berberine, and the Garlic extract has 0.2% Allicin. This formula also contains Caprylic acid for additional anti-bacterial and anti-fungal support. It was the only product we found that contains BioPerine® for enhanced nutrient absorption and quicker results. 

Quality: Approved Science Siboprin contains high-grade, natural, clinically-verified ingredients. It does not contain any additives or preservatives and is 100% safe to use. 

Reputation: Approved Science’s reputation is top quality. They are well known in the industry and are an established company that provides great customer support service, secure and easy checkout, and prompt, efficient delivery. This manufacturer has several third-party monitoring services, including buySAFE, Norton, and Trustee, as well as an A+ rating from the quality monitoring company QualityTrusted. Approved Science’s commitment to the health industry and consumers is excellent, providing further legitimacy to their products by producing them in an FDA-registered facility with GMP certification.

Money-Back Guarantee: Every item sold is supported by a 60-day 100% money-back guarantee. Such guarantees from manufacturers show strong confidence in their products’ ability to deliver results. Great news for consumers.

Bottom Line: If you are looking for a product that ticks all the boxes for an effective SIBO supplement that comes from an established, reputable company with an excellent money-back guarantee, then this is the supplement for you.

It would be good to note that, due to high demand, Approved Science Siboprin is often sold out. To avoid having to back order, don’t hesitate to make that purchase when you see it in stock.

See The Full Review


Rating: Good



Amy Myers MD Microb-Clear

Marketed as a supplement that supports healthy balance in the gut and reduces SIBO, bloating, leaky gut, and constipation, Amy Myers MD Microb-Clear is our second choice. With 200mg of Berberine, as well as Caprylic acid, minerals and other botanical extracts, we felt that Microb-Clear emerged as a strong contender overall.

As far as formulas go, this one looks promising, but it is unclear if this formula will actually be effective. Although the ingredients are pure and high quality, some crucial ingredients have been omitted, such as Oregano. There is also no addition of a bioavailability enhancer such as BioPerine®, or other Black Pepper extract, which will affect the overall effectiveness of this product. 

Microb-Clear is manufactured in a facility where all products are third-party tested and verified, which adds assurance that each element is what it’s supposed to be, and meets all Good Manufacturing Practice standards set forth by the FDA. It is free of unnecessary ingredients and contaminants, and does not use GMOs, although those who have nut allergies should be aware that this product contains walnuts. We were also pleased to see a price tag that suggests quality, and an impressive 90-day return policy. These are all elements that endorse a product. Read our full review of pros and cons before you buy Microb-Clear.

Click here to read the full review


Rating: OK


 Integrative Therapeutics Berberine Complex

Our third pick provides the recommended dosage of 400mg Barberry Root extract. Berberine Complex also contains 400mg of Oregon Grape and 100mg Goldenseal. But is a product that focuses on various forms of Berberine as effective for SIBO as a product with a greater variety of ingredients

We appreciate that Berberine, the active constituent proven to help with symptoms of SIBO, is the star ingredient of this formula. We took into account that while SIBO is not specifically mentioned in Integrative Therapeutics’ marketing of this product, we felt that it qualified for our product comparison nonetheless. Not only was it formulated to support the healthy balance of bacteria, but with a diverse array of 38 products solely focused on gastrointestinal support, this company demonstrates a comprehensive understanding and expertise in the field of gut health, thus deserving significant attention and consideration.   

When reviewing this product, we were pleased to find a price that indicates a level of quality that is neither inexpensive nor overly costly. We also liked that the product comes from a well established brand and that the reviews for this product were mainly positive. The manufacturer follows the GMP guidelines and guarantees their products undergo rigorous testing. Yet, unlike our other top picks, this manufacturer appears to lack a satisfaction guarantee, and their return policy does not inspire the same level of confidence. Read our full review for more about how this product stacks up.

Click here to read the full review

What You’ll Discover:

Which SIBO supplement is the BEST BUY and comes with a great GUARANTEE!
Which formula and ingredients are the most EFFECTIVE and work the fastest?
How NOT to get ripped off! BE AWARE of poor quality and cheap products.

Top 6 Items to Consider:

  1. Ingredients
  2. Cost Per Serving
  3. Product Testing Results
  4. Company Reputation
  5. Consumer Reviews
  6. Return Policy & Satisfaction Guarantee

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