SIBO Product Buyer’s Guide (updated May 2024)

Information About SIBO

SIBO, or Small Intestinal Bacterial Overgrowth, is a condition characterized by the excessive growth of bacteria in the small intestine. Normally, the small intestine has a relatively low concentration of bacteria compared to the large intestine. However, in SIBO, the bacteria from the large intestine migrate and multiply in the small intestine, causing an imbalance in the gut microbiome. This condition can be triggered by various factors, including underlying digestive or immune disorders. 

For individuals struggling with SIBO, it can be of paramount importance to seek treatment and get rid of the condition. SIBO can lead to a wide range of uncomfortable symptoms, including bloating, abdominal pain, diarrhea, constipation, and excessive gas. These symptoms can significantly impact an individual’s quality of life, causing discomfort, embarrassment, and disruption in daily activities. Furthermore, if left untreated, SIBO can interfere with the absorption of important nutrients from food, leading to malnutrition and deficiencies. Therefore, addressing SIBO and restoring a healthy balance of gut bacteria becomes crucial for regaining digestive health and overall well-being.

Unfortunately, the market is saturated with low quality SIBO supplements that are inefficient and unhelpful. However, clinical studies have shown that many high quality products do actually work to target small intestinal bacterial overgrowth and improve health. Our research has shown that, given the correct dosage and potency of specific ingredients, from a reputable manufacturer that has based their product upon scientific research and clinical data, you can achieve the results that you want. The bottom line is that there are SIBO products that will do exactly what they say they will – you just have to find them.

Key points to consider when choosing a SIBO supplement

There are several key elements which make a highly effective, top-quality SIBO supplement.  Utilizing specific herbs with strong antimicrobial properties can be a highly effective way to relieve SIBO symptoms by tapping into their natural healing abilities. These include an optimal dosage of three key herbs – Oregano, Barberry, and Garlic. Many companies will not disclose the percentage of the beneficial compounds, but what you really want is at least 5% Berberine and 0.2% Allicin for the most powerful benefits. For even better results it must be paired with Caprylic acid, which not only targets unwanted bacteria, fungus and yeast, but simultaneously helps the beneficial bacteria to flourish. Finally, you should look for the inclusion of a bioavailability enhancer, such as BioPerine®, to increase nutrient absorption and maximize the results. 

When choosing a SIBO supplement, you should look for a company with a strong reputation that sells a wide range of natural, nutritional supplements. An effective supplement will be formulated using high-quality ingredients that have been proven effective in clinical trials. It will also be GMP certified and made in an FDA-approved facility. Many supplement manufacturers make grand promises of renewed health, only for you to find out later that there is no real change and you are left with an empty bottle, empty purse, and empty promises. Don’t be dismayed – there are some that really do work! You just need to find a legitimate product.

If you come across a company selling SIBO supplements using strong marketing terms or slogans, or if they are endorsed by famous celebrities, you should stay clear. If the company and product formula don’t speak for themselves, then nothing else should.

What makes a SIBO supplement effective?

The secret is simply in the formula! The correct dosage and potency of clinically proven key ingredients, plus third-party testing for purity and safety, have been shown to be essential for an ideal SIBO supplement.

Should you decide that a SIBO supplement is for you, and you would like to try a top-quality product, check out our reviews for a number of SIBO supplements that are currently available on the market. We examined numerous products for their ingredients, consumer feedback, business reputation and more, in order to help you discover which supplements are the real deal. No more guesswork. We have done all the hard work for you – your search for answers is over!

Our recommended choice stands above and beyond the competition and we think you will agree. The company’s excellent reputation, high-quality product, and external independent monitoring and testing are enough to earn a high ranking. When you consider all of those factors together with the incredible money-back guarantee policy, Approved Science Siboprin becomes a product that you are going to want to take a closer look at.

SIBO Report

Rating: Excellent


Money-Back Guarantee
Consumer Feedback
Company Reputation

Editor’s Choice

Approved Science Siboprin

If you want to try a powerful supplement to eliminate unwanted bacteria, alleviate SIBO symptoms, reduce inflammation, and improve gut health, then Approved Science Siboprin is something that deserves your undivided attention. Of all the SIBO supplements currently available on the market, this is the one that deserves a closer look and very likely, the one that will change your life!

It contains the recommended herbal ingredients of Oregano, Garlic, and Barberry in a unique Micro-Sci™ Herbal Complex – a synergistic combination to ensure that unwanted bacteria in the small intestines are killed off in an efficient manner. Not only are there substantial quantities of each herb, but they also contain optimal amounts of the most potent constituents: the Barberry extract is standardized to 5% Berberine, and the Garlic extract has 0.2% Allicin. This formula also contains Caprylic acid for additional anti-bacterial and anti-fungal support. It was the only product we found that contains BioPerine® for enhanced nutrient absorption and quicker results. 

Quality: Approved Science Siboprin contains high-grade, natural, clinically-verified ingredients. It does not contain any additives or preservatives and is 100% safe to use. 

Reputation: Approved Science’s reputation is top quality. They are well known in the industry and are an established company that provides great customer support service, secure and easy checkout, and prompt, efficient delivery. This manufacturer has several third-party monitoring services, including buySAFE, Norton, and Trustee, as well as an A+ rating from the quality monitoring company QualityTrusted. Approved Science’s commitment to the health industry and consumers is excellent, providing further legitimacy to their products by producing them in an FDA-registered facility with GMP certification.

Money-Back Guarantee: Every item sold is supported by a 60-day 100% money-back guarantee. Such guarantees from manufacturers show strong confidence in their products’ ability to deliver results. Great news for consumers.

Bottom Line: If you are looking for a product that ticks all the boxes for an effective SIBO supplement that comes from an established, reputable company with an excellent money-back guarantee, then this is the supplement for you.

It would be good to note that, due to high demand, Approved Science Siboprin is often sold out. To avoid having to back order, don’t hesitate to make that purchase when you see it in stock.

See The Full Review


Rating: Good



Amy Myers MD Microb-Clear

Marketed as a supplement that supports healthy balance in the gut and reduces SIBO, bloating, leaky gut, and constipation, Amy Myers MD Microb-Clear is our second choice. With 200mg of Berberine, as well as Caprylic acid, minerals and other botanical extracts, we felt that Microb-Clear emerged as a strong contender overall.

As far as formulas go, this one looks promising, but it is unclear if this formula will actually be effective. Although the ingredients are pure and high quality, some crucial ingredients have been omitted, such as Oregano. There is also no addition of a bioavailability enhancer such as BioPerine®, or other Black Pepper extract, which will affect the overall effectiveness of this product. 

Microb-Clear is manufactured in a facility where all products are third-party tested and verified, which adds assurance that each element is what it’s supposed to be, and meets all Good Manufacturing Practice standards set forth by the FDA. It is free of unnecessary ingredients and contaminants, and does not use GMOs, although those who have nut allergies should be aware that this product contains walnuts. We were also pleased to see a price tag that suggests quality, and an impressive 90-day return policy. These are all elements that endorse a product. Read our full review of pros and cons before you buy Microb-Clear.

Click here to read the full review


Rating: OK


 Integrative Therapeutics Berberine Complex

Our third pick provides the recommended dosage of 400mg Barberry Root extract. Berberine Complex also contains 400mg of Oregon Grape and 100mg Goldenseal. But is a product that focuses on various forms of Berberine as effective for SIBO as a product with a greater variety of ingredients

We appreciate that Berberine, the active constituent proven to help with symptoms of SIBO, is the star ingredient of this formula. We took into account that while SIBO is not specifically mentioned in Integrative Therapeutics’ marketing of this product, we felt that it qualified for our product comparison nonetheless. Not only was it formulated to support the healthy balance of bacteria, but with a diverse array of 38 products solely focused on gastrointestinal support, this company demonstrates a comprehensive understanding and expertise in the field of gut health, thus deserving significant attention and consideration.   

When reviewing this product, we were pleased to find a price that indicates a level of quality that is neither inexpensive nor overly costly. We also liked that the product comes from a well established brand and that the reviews for this product were mainly positive. The manufacturer follows the GMP guidelines and guarantees their products undergo rigorous testing. Yet, unlike our other top picks, this manufacturer appears to lack a satisfaction guarantee, and their return policy does not inspire the same level of confidence. Read our full review for more about how this product stacks up.

Click here to read the full review

What You’ll Discover:

Which SIBO supplement is the BEST BUY and comes with a great GUARANTEE!
Which formula and ingredients are the most EFFECTIVE and work the fastest?
How NOT to get ripped off! BE AWARE of poor quality and cheap products.

Top 6 Items to Consider:

  1. Ingredients
  2. Cost Per Serving
  3. Product Testing Results
  4. Company Reputation
  5. Consumer Reviews
  6. Return Policy & Satisfaction Guarantee

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